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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Pilocytic astrocytoma


Other Names for this Disease
  • Juvenile pilocytic astrocytoma
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Inheritance


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Are pilocytic astrocytomas inherited?

Pilocytic astrocytomas are typically sporadic, occurring by chance in individuals with no history of the condition in the family. Sporadic abnormalities are not inherited from a parent and are not likely to recur in a family. Familial cases of isolated astrocytomas are very rare.[1]

Although most individuals with a pilocytic astrocytoma do not have an underlying genetic condition, astrocytomas have been associated with a few "predisposing" genetic syndromes. Individuals with these syndromes will not necessarily develop one; these tumors just occur with a greater frequency in affected individuals. Genetic syndromes in which astrocytomas have been reported to occur include:[1]

All of these genetic conditions follow an autosomal dominant pattern of inheritance. Individuals who are interested in learning about personal genetic risks for these conditions and/or genetic testing options for themselves or family members should speak with a genetics professional.

Last updated: 8/14/2013

References
  1. Jacques Grill. Astrocytoma. Orphanet. November 2007; http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=GB&Expert=94. Accessed 8/14/2013.