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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Leukonychia totalis


Other Names for this Disease

  • Hereditary white nails
  • Nail disorder, nonsyndromic congenital, 3
  • NDNC3
  • Porcelain nails
  • Total leukonychia
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Inheritance

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Is leukonychia totalis inherited?

Leukonychia totalis can be inherited in either an autosomal dominant or autosomal recessive manner. It may also occur as part of various underlying conditions or abnormalities, some of which have their own specific genetic cause(s) and inheritance patterns. In some cases, the condition is idiopathic (of unknown cause).[1][2][3]

Autosomal dominant inheritance means that having a change (mutation) in only one copy of the disease-causing gene is enough to cause signs or symptoms. When a person with an autosomal dominant condition has children, each child has a 50% (1 in 2) risk to inherit the mutated copy of the gene.

Autsomal recessive inheritance means that a person must have mutations in both copies of the disease-causing gene to have the condition. Usually, one mutated copy is inherited from each parent, who are each referred to as a carrier.  Carriers of an autosomal recessive condition typically do not have any signs or symptoms.
Last updated: 2/19/2014

References
  1. Yalçin Tüzün, Özge Karakus. Leukonychia. J Turk Acad Dermatol. 2009; 3(1):Accessed 2/18/2014.
  2. Balighi K, Moeineddin F, Lajevardi V, Ahmadreza R. A family with leukonychia totalis. Indian J Dermatol. 2010; 55(1):102-104. Accessed 2/18/2014.
  3. Lee YB, Kim JE, Park HJ, Cho BK. A case of hereditary leukonychia totalis and partialis. Int J Dermatol. February, 2011; 50(2):233-234. Accessed 2/18/2014.


Other Names for this Disease
  • Hereditary white nails
  • Nail disorder, nonsyndromic congenital, 3
  • NDNC3
  • Porcelain nails
  • Total leukonychia
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.