Your browser does not support javascript:   Search for gard hereSearch for news-and-events here.


Genetic and Rare Diseases Information Center (GARD)

Print friendly version

Kyrle disease

Other Names for this Disease
  • Hyperkeratosis follicularis et parafollicularis in cutem penetrans
  • Kyrle's disease
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.


Newline Maker

What causes Kyrle disease?

The cause of Kyrle disease is currently unknown. Some cases appear to be idiopathic (no known triggers), or inherited. What has been found is that Kyrle disease appears to occur more frequently in patients with certain systemic disorders, which include diabetes mellitus; renal disease (chronic renal failure, albuminuria, elevated serum creatinine, abnormal creatinine clearance, polyuria); hepatic abnormalities (alcoholic cirrhosis); and congestive heart failure.[1] It has been thought that metabolic disorders associated with Kyrle disease are somehow responsible for development of abnormal keratinization and connective tissue changes, but the exact mechanism by which this happens is unclear.[2]
Last updated: 6/16/2011

  1. Kyrle disease. DermNet NZ. June 15, 2009; Accessed 6/16/2011.
  2. Kalla G, Kachhawa, Goyal MA, Mathur RD. Kyrle's disease. Indian J Dermatol Venereol Leprol. 1995; 61:239-240.;year=1995;volume=61;issue=4;spage=239;epage=240;aulast=Kalla. Accessed 6/16/2011.