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Genetic and Rare Diseases Information Center (GARD)

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Alpha mannosidosis type 2

Other Names for this Disease
  • Alpha-mannosidosis adult-onset form
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What is the typical long-term outlook for people with alpha mannosidosis type 2?

There is limited information regarding long-term outlook for people with alpha mannosidosis. Much of the literature describes cases in children. Frequency of infections, such as colds, pneumonia, ear infection, and stomach flu is often worse in early childhood and improves with age. Muscle weakness and central nervous system disease (e.g., cerebellar disorders) tend to become evident in adolescence to early adulthood. These symptoms tend to slowly worsen overtime. Intellectual disability is common and adults tend to have an IQ of 60-80. Intellectual disability remained stable in some, but not all reported cases.  Bone involvement is highly variable, but symptoms may decrease with age. While people with alpha mannosidosis have lived well into adulthood, there is very limited data regarding life expectancy and cause of death in affected adults.[1][2]
Last updated: 10/1/2013

  1. Malm D, Nilssen O. Alpha-Mannosidosis. GeneReview. 2001; Accessed 10/1/2013.
  2. MANNOSIDOSIS, ALPHA B, LYSOSOMAL. OMIM. Updated July 17, 2012; Accessed 10/1/2013.