Alpha mannosidosis type 2
Other Names for this Disease
- Alpha-mannosidosis adult-onset form
What are the signs and symptoms of alpha mannosidosis type 2?
How might alpha mannosidosis type 2 be treated?
What is the typical long-term outlook for people with alpha mannosidosis type 2?
More common signs and symptoms of alpha mannosidosis type 2 include:
Developmental delays (e.g., motor and speech)
Weakened immune system
Cerebellar disorders (e.g., ataxia)
Occasional psychiatric symptoms (e.g., depression, anxiety, or hallucinations)
Enlarged liver and spleen (with normal function)
People with alpha-mannosidosis type 2 often have distinct facial features, including large head size, large forehead, low hair line, rounded eyebrows, large ears, wide spaced teeth, overgrown gums, large tongue, protruding jaw, and flattened bridge of the nose.
Current treatment options for alpha mannosidosis may include bone marrow transplant or peripheral blood stem cell transplantation. Enzyme replacement therapy may be an additional treatment option in the future.
Treatments to address individual symptoms are recommended as needed, such as vaccinations, antibiotics, hearing aids, glasses, orthopedic and other assistive devices, educational interventions, and speech therapy. Regular follow-up to monitor health and treatment response is advised.
Further detailed information on treatment is available at the following link to GeneReviews.
- Alpha-Mannosidosis. Genetics Home Reference. 2007; http://www.ghr.nlm.nih.gov/condition/alpha-mannosidosis. Accessed 10/1/2013.
- Malm D, Nilssen O. Alpha-Mannosidosis. GeneReview. 2001; http://www.ncbi.nlm.nih.gov/books/NBK1396/. Accessed 10/1/2013.
- MANNOSIDOSIS, ALPHA B, LYSOSOMAL. OMIM. Updated July 17, 2012; http://omim.org/entry/248500. Accessed 10/1/2013.