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Multicentric Castleman’s Disease

Other Names for this Disease
  • Idiopathic multicentric Castleman's disease
  • MCD
  • Multicentric plasma cell variant of Castleman's disease
  • Plasmablastic multicentric Castleman disease
  • PMCD
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Multicentric Castleman’s disease is a type of Castleman's disease that affects more than a single group of lymph nodes. It can also affect other organs containing lymphoid tissue. People with multicentric Castleman's disease often have serious infections, fevers, weight loss, fatigue, night sweats, and nerve damage that can cause weakness and numbness. Blood tests may indicate anemia and high levels of antibodies in the blood (hypergammaglobulinemia). They may also experience loss of appetite, nausea, vomiting, and enlarged liver and spleen. Multicentric Castleman disease can weaken the immune system, making it hard to fight infection. Infections in people with multicentric Castleman's disease can be very serious and may even be fatal. Multicentric Castleman's disease acts very much like lymphoma. In fact, about 20% of people with this disease eventually develop lymphoma. Treatment may involve surgery, chemotherapy or radiation therapy.[1][2] 
Last updated: 8/18/2011


  1. Detailed Guide: Castleman Disease. American Cancer Society. 2011; Accessed 8/18/2011.
  2. Castleman disease. 2009; Accessed 8/18/2011.
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Basic Information

  • The American Cancer Society provides detailed information about Castleman's disease. Click on the link to access this information. 
  • provides an information page for this topic. Click on the link to view this information.
  • The National Organization for Rare Disorders (NORD) is a federation of more than 130 nonprofit voluntary health organizations serving people with rare disorders. Click on the link to view information on this topic.

In Depth Information

  • Orphanet is a European reference portal for information on rare diseases and orphan drugs.  Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Multicentric Castleman’s Disease. Click on the link to view a sample search on this topic.

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