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Genetic and Rare Diseases Information Center (GARD)

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Adenosarcoma of the uterus


Other Names for this Disease
  • Mullerian adenosarcoma of the uterus
  • Uterine adenosarcoma
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Your Question

Is there a genetic link involved in this disease? I was recently diagnosed with it and wonder if my sister or other female relatives should be tested. Also how can I best keep up with the news? I'm not looking for technical treatises on mice but for practical information such as the effects of diet, exposure to pesticides, etc.

Our Answer

We have identified the following information that we hope you find helpful. If you still have questions, please contact us.

What causes adenosarcoma of the uterus?

The exact cause of adenosarcoma of the uterus is not always known. The development of these tumors has been associated with a few risk factors. Risk factors are associated with an increased risk of developing a condition; however, most people with these risk factors will never develop the condition. Factors that have reportedly been associated with development of adenosarcoma of the uterus include hyperestrinism (abnormally high levels of estrogenic hormones in the body), prior chemotherapy, prior radiotherapy and tamoxifen therapy (used as an adjuvant drug for breast cancer).[1][2][3]
Last updated: 10/12/2012

Is adenosarcoma of the uterus inherited?

To our knowledge, there have not been reports of familial cases of adenosarcoma of the uterus, nor have there been reports of a particular gene being linked to this specific type of tumor. Some types of uterine cancer and/or endometrial cancer are known to be associated with hereditary cancer syndromes, but we are unaware of information about an association between these cancer syndromes and uterine adenosarcoma specifically.

Individuals who are interested in learning about how their personal or family history of cancer may affect other family members should speak with an oncologist or genetics professional. These health care providers can help determine whether genetic testing for an inherited susceptibility to cancer is appropriate and/or available.
Last updated: 10/12/2012

How can I stay informed about the most up-to-date information on adenosarcoma of the uterus?

You can find relevant articles on adenosarcoma of the uterus through PubMed, a searchable database of biomedical journal articles. Although not all of the articles are available for free online, most articles listed in PubMed have a summary available. To obtain the full article, contact a medical/university library or your local library for interlibrary loan. You can also order articles online through the publisher’s Web site. Using "adenosarcoma of the uterus" or "uterine adenosarcoma" as your search term should help you locate articles. Use the advanced search feature to narrow your search results. Click here to view a sample search.

The National Library of Medicine (NLM) Web site has a page for locating libraries in your area that can provide direct access to these journals (print or online). The Web page also describes how you can get these articles through interlibrary loan and Loansome Doc (an NLM document-ordering service). You can access this page at the following link http://nnlm.gov/members/. You can also contact the NLM toll-free at 888-346-3656 to locate libraries in your area.
Last updated: 10/12/2012

How can I find a genetics professional in my area?

Genetics clinics are a source of information for individuals and families regarding genetic conditions, treatment, inheritance, and genetic risks to other family members. More information about genetic consultations is available from Genetics Home Reference. To find a genetics clinic, we recommend that you contact your primary healthcare provider for a referral.

The following online resources can help you find a genetics professional in your community:
Last updated: 10/18/2013

References
  • Sinha A, Phukan JP, Sengupta S, Guha P. Mullerian adenosarcoma of uterus with sarcomatous overgrowth and heterologous component associated with stromal deposit in omentum: a case report and review of the literature. Case Report Med. 2012; ePub:
  • Tjalma WA, Michener CM. Mullerian adenosarcoma of the uterus associated with long-term oral contraceptive use. Eur J Obstet Gynecol Reprod Biol. April 1, 2005; 119(2):253-254..
  • Arici DS, Aker H, Yildiz E, Tasyurt A. Mullerian adenosarcoma of the uterus associated with tamoxifen therapy. Arch Gynecol Obstet. September 2000; 264(2):105-107.