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Thrombocytopenia, acquired amegakaryocytic

Other Names for this Disease
  • AAT
  • Acquired pure megakaryocytic aplasia
  • Severe thrombocytopenia and selective, marked decrease or absence of megakaryocytes
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Acquired amegakaryocytic thrombocytopenia is characterized by severe thrombocytopenia (lack of platelets) with no other blood abnormalities.[1] It is so named because the level of the large bone marrow cells that produce platelets, called megakaryocytes, are significantly lower or absent. The course of the condition is variable, but the condition can become life-threatening. Its cause is currently unknown.[1]
Last updated: 6/10/2009


  1. Bulcahndani D et al.,. Acquired pure megakaryocytic aplasia: Report of a single case treated with Mycophenolate Mofetil. American Journal of Hematology. 2007;
  2. Felderbauer P et al.,. Case Report: Acquired pure megakaryocytic aplasia: a seoarate haematological disease entity or a syndrome with multiple causes?. Eur J Haematol. 2004;
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