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Genetic and Rare Diseases Information Center (GARD)

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Acute fatty liver of pregnancy


Other Names for this Disease

  • Acute fatty liver, gestational
  • AFLP
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Overview

Acute fatty liver of pregnancy (AFLP) is a rare and serious complication of pregnancy. It is characterized by a build-up of fat in the liver, which can lead to liver damage. The cause of AFLP is not well understood, but genetics may play a role. Symptoms generally begin in the third trimester and may include persistent nausea and vomiting, pain in the stomach or upper-right abdomen, malaise, jaundice and headache. Without prompt treatment, AFLP can lead to coma, organ failure or death of the mother and baby. Treatment involves stabilizing the mother and delivery of the baby.[1][2] 
Last updated: 8/25/2014

References

  1. Liver disorders. March of Dimes. 2014; http://www.marchofdimes.org/pregnancy/liver-disorders.aspx. Accessed 8/25/2014.
  2. Finke A. Acute Fatty Liver of Pregnancy. University of Rochester Medical Center Health Encyclopedia. 2014; http://www.urmc.rochester.edu/Encyclopedia/Content.aspx?ContentTypeID=90&ContentID=P02465. Accessed 8/25/2014.
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Other Names for this Disease
  • Acute fatty liver, gestational
  • AFLP
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.