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Genetic and Rare Diseases Information Center (GARD)

Other Names for this Disease
  • GSM 1
  • Hereditary chin tremor/myoclonus
  • Hereditary geniospasm
  • Trembling chin
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How might hereditary geniospasm be treated?

Hereditary geniospasm, which may also be referred to as hereditary essential chin myoclonus, is generally considered a benign disorder although in some cases it can cause anxiety and social embarrassment.[1] Significant improvement with age has been reported.[2] Several drugs are used to treat myoclonus, such as benzodiazepines and anticonvulsants. However, individuals may not respond to a single medication and may experience significant side effects if a combination of drugs is used. It has also been suggested that botulinum toxin be considered as a primary treatment because it has been shown to be effective and well tolerated.[1]
Last updated: 6/5/2013

  1. Devetag Chalaupka F, Bartholini F, Mandich G, Turro M. Two new families with hereditary essential chin myoclonus: clinical features, neurophysiological findings and treatment. Neurol Sci. June 2006; 27(2):97-103.
  2. Hereditary geniospasm. Orphanet. April 2009; Accessed 6/5/2013.

Clinical Trials & Research for this Disease

  • The Centers for Mendelian Genomics program is working to discover the causes of rare genetic disorders. For more information about applying to the research study, please visit their website.