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Genetic and Rare Diseases Information Center (GARD)

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Alzheimer disease type 1

Other Names for this Disease
  • AD1
  • Alzheimer disease 1
  • Early-onset familial form of Alzheimer disease
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Alzheimer disease is a degenerative disease of the brain that causes gradual loss of memory, judgment, and ability to function socially. Alzheimer disease currently affects about 5 million people.[1] About 75 percent of Alzheimer disease cases are classified as sporadic, which means they occur in people with no history of the disorder in their family. Although the cause of these cases is unknown, genetic changes are likely to play a role. Virtually all sporadic Alzheimer disease begins after age 65, and the risk of developing this condition increases as a person gets older.

The remaining cases of Alzheimer disease are familial, which means they are found in multiple members of a family. Familial Alzheimer disease can be divided into early-onset disease (symptoms begin before age 65) and late-onset disease (symptoms begin after age 65).[2]

Last updated: 7/2/2013


  1. Alzheimer Disease. Genetics Home Reference. October 2006; Accessed 1/18/2008.
  2. Alzheimer's Facts and Figures. Alzheimer's association. October 16, 2007; Accessed 1/18/2008.
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Basic Information

  • Genetics Home Reference (GHR) contains information on Alzheimer disease type 1. This website is maintained by the National Library of Medicine.
  • The National Institute on Aging (NIA) leads a national program of research on the biomedical, social, and behavioral aspects of the aging process; the prevention of age-related diseases and disabilities; and the promotion of a better quality of life for all older Americans. Click on the link to view information on this topic. 
  • The National Institutes of Health (NIH) has developed a fact sheet on Alzheimer's disease.  To view this fact sheet, click on the link below.

In Depth Information

  • The Online Mendelian Inheritance in Man (OMIM) is an catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine. 
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Alzheimer disease type 1. Click on the link to view a sample search on this topic.

Resources for Kids

  • The Alzherimer's Association provides videos and information to help kids and teens deal with the emotions and reactions that are common when a loved one is diagnosed with Alzheimer’s. Click on Alzheimer's Association to view these resources.

Press Releases


  • Learn how Alzheimer's disease affects the brain through the Alzheimer's Association's interactive Brain Tour

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