Alzheimer disease type 1
Other Names for this Disease
- Alzheimer disease 1
- Early-onset familial form of Alzheimer disease
What is early-onset Alzheimer disease and how is it inherited?
The remaining cases of Alzheimer disease are familial, which means they are found in multiple members of a family. Familial Alzheimer disease can be divided into early-onset disease (symptoms begin before age 65) and late-onset disease (symptoms begin after age 65).
Early-onset Alzheimer disease is often inherited in an autosomal dominant manner, meaning that the risk to offspring of an individual with early-onset familial Alzheimer disease is 50% if a mutation is found in APP, PSEN1, or PSEN2. Occasionally, neither parent is affected, but a second-degree relative (e.g., an uncle, aunt and/or grandparent) has or had early-onset Alzheimer disease.
You can read a comprehensive review of early-onset Alzheimer disease on the GeneReviews Web site.
- Alzheimer Disease. Genetic Home Reference. October 2006; http://ghr.nlm.nih.gov/condition=alzheimerdisease. Accessed 1/18/2008.
- Alzheimer's Facts and Figures. Alzheimer's association. October 16, 2007; http://www.alz.org/alzheimers_disease_facts_figures.asp. Accessed 1/18/2008.