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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Brenner tumor of ovary


Other Names for this Disease
  • Ovarian Brenner tumor
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Overview



What is a Brenner tumor of the ovary?

What are the signs and symptoms of a Brenner tumor of the ovary?

How is a Brenner tumor of the ovary diagnosed?

What treatments might be available for Brenner tumors of the ovary?


What is a Brenner tumor of the ovary?

A Brenner tumor of the ovary is a small, firm, smooth and solid growth (tumor) on the ovary.  Brenner tumors of the ovary usually do not cause symptoms.[1][2][3]  Approximately 2% of all ovarian tumors are Brenner tumors.  There are three forms of this tumor: benign, proliferative (low chance of spreading beyond the original location of the tumor), and malignant.[1][2]  The current preferred term for benign Brenner tumors of the ovary is transitional cell tumors.[2]  These tumors usually occur in women ages 40 to 60 years.[2]  Treatment usually consists of surgery to remove the tumor.[2][3]  If a Brenner tumor has not spread into surrounding tissues or to more distant parts of the body, there is a good-to-excellent prognosis.[1]
Last updated: 1/11/2012

What are the signs and symptoms of a Brenner tumor of the ovary?

Most Brenner tumors do not cause any symptoms.  If a Brenner tumor is quite large, it may cause pain or discomfort in one side of the abdomen.  Postmenopausal bleeding (showing signs of a menstrual period after menopause) is sometimes associated with Brenner tumors, as endometrial hyperplasia also occurs in 10% to 16% of cases of Brenner tumors.[2]
Last updated: 1/11/2012

How is a Brenner tumor of the ovary diagnosed?

Approximately 90% of Brenner tumors of the ovary are discovered by chance during a gynecologic operation.[2] They often occur at the same time as other ovarian tumors or cancers.[1][3]  Most benign Brenner tumors make a protein called p63.  Because other ovarian tumors and malignant Brenner tumors do not make this protein, p63 is considered a tumor marker for Brenner tumors of the ovary.  Therefore, if p63 is identified in a patient, this may help to diagnose a Brenner tumor of the ovary.[3]
Last updated: 1/11/2012

What treatments might be available for Brenner tumors of the ovary?

Treatment of Brenner tumors of the ovary usually consists of surgery to remove the tumor.[2][3]  The age of the patient may be a factor in deciding the extent of the operation.[2]
Last updated: 1/11/2012

References
  1. Curran D. Benign Lesions of the Ovaries. eMedicine. 2011; http://emedicine.medscape.com/article/265548-overview#aw2aab6b4. Accessed 1/11/2012.
  2. Katz VL, Lentz GM, Lobo RA, Gershenson DM. Comprehensive Gynecology, 5th edition. Philadelphia, PA: Mosby Elsevier; 2007;
  3. Stany MP, Hamilton CA. Obstet Gynecol Clin North Am. 2008; 35:271-284. http://www.ncbi.nlm.nih.gov/pubmed/18486841. Accessed 1/11/2011.