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Only a small proportion of pineoblastomas are thought to be inherited. Of the inherited pineoblastomas, most are associated with changes (mutations) in the RB1 gene, which are usually associated with an increased chance of developing eye tumors known as retinoblastomas. A few articles have suggested that inherited changes in the APC gene, which are usually associated with an increased chance to develop colon cancer and brain tumors, might contribute to the development of a small number of pineoblastomas. There has been a report of a mother and daughter both developing pineoblastoma, which suggests that there may be other inherited causes of this tumor.
Last updated: 12/15/2011
- Li MH, Bouffet E, Hawkins CE, Squire JA, Huang A. Molecular genetics of supratentorial primitive neuroectodermal tumors and pineoblastoma. Neurosurgical Focus. 2005; 19:E3. http://www.ncbi.nlm.nih.gov/pubmed/16398467. Accessed 12/12/2011.
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- Lesnick JE, Chayt KJ, Bruce DA, Rorke LB, Trojanowski J, Savino PJ, Schatz NJ. Familial pineoblastoma. Report of two cases. Journal of Neurosurgery. 1985; 62:930-932. http://www.ncbi.nlm.nih.gov/pubmed/3998847. Accessed 12/12/2011.