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Diseases

Genetic and Rare Diseases Information Center (GARD)

Other Names for this Disease
  • Nodose hair
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Inheritance


Newline Maker

How do people inherit monilethrix?

Monilethrix can be inherited in an autosomal dominant or autosomal recessive manner.[1][2] In autosomal dominant conditions, a single copy of the disease-associated mutation is enough to cause the disease. In many cases, an individual inherits the condition from a parent. In autosomal recessive conditions, two copies of the mutation, one from each parent, are needed to cause the disease. The parents of an individual with an autosomal recessive condition each carry one copy of the mutated gene, but they typically do not show signs and symptoms of the condition.
Last updated: 1/30/2012

References
  1. Monilethrix. Online Mendelian Inheritance in Man (OMIM). May 6, 2010; http://omim.org/entry/158000. Accessed 1/30/2012.
  2. Farooq M, Ito M, Naito M, Shimomura Y. A case of monilethrix caused by novel compound heterozygous mutations in the desmoglein 4 (DSG4) gene. Br J Dermatol. 2011; http://www.ncbi.nlm.nih.gov/pubmed/21495994. Accessed 1/30/2012.