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Genetic and Rare Diseases Information Center (GARD)

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Pyridoxine-dependent epilepsy

Other Names for this Disease
  • Pyridoxine dependency
  • Pyridoxine dependency with seizures
  • Vitamin B6-dependent seizures
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  • My daughter was diagnosed with pyridoxine-dependent epilepsy at birth. Her symptoms were controlled until a few years ago when she began to have muscle stiffness in the hands and legs, partial seizures, and loss of her voice. Her seizures now occur almost daily and are quite violent. Her doctors believe that her seizure activity may now be the result of psychogenic nonepileptic seizures (PNES). Is this a common occurrence in adults with pyridoxine-dependent epilepsy? Click here for answer