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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Chiari malformation type 1

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* Not a rare disease
Other Names for this Disease
  • Arnold Chiari malformation type I
  • Chiari malformation type I
  • Chiari type I malformation
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Cause


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What causes Chiari malformation type 1?

Primary or congenital Chiari malformations are caused by structural defects in the brain and spinal cord that occur during fetal development. The underlying cause of the structural defects are not completely understood, but may involve genetic mutations or lack of proper vitamins or nutrients in the maternal diet.[1]

Less frequently, Chiari malformation type 1 is acquired after birth. Causes of acquired Chiari malformation type 1 involve the excessive draining of spinal fluid from the lumbar or thoracic areas of the spine as a result of injury, exposure to harmful substances, or infection.[1] Click here to view a diagram of the spine.

Last updated: 3/12/2012

References
  1. Chiari Malformation Fact Sheet. National Institute of Neurological Disorders and Stroke Web site. 2009; http://www.ninds.nih.gov/disorders/chiari/detail_chiari.htm. Accessed 12/22/2009.