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Tarsal carpal coalition syndrome

Other Names for this Disease
  • TCC
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Tarsal carpal coalition syndrome is a genetic condition characterized by fusion of the bones in the wrist (carpals), feet (tarsals), and the fingers and toes (phalanges). Other bone abnormalities in the hands and feet may be present. Approximately 10 affected families have been described. Tarsal carpal coalition syndrome is caused by mutations in the NOD gene, and it is inherited in an autosomal dominant pattern.[1]
Last updated: 6/22/2009


  1. Tarsal-carpal coalition syndrome. Orphanet. September 2007; Accessed 6/22/2009.
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Basic Information

  • Genetics Home Reference (GHR) contains information on Tarsal carpal coalition syndrome. This website is maintained by the National Library of Medicine.

In Depth Information

  • The Online Mendelian Inheritance in Man (OMIM) is an catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine. 
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs.  Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Tarsal carpal coalition syndrome. Click on the link to view a sample search on this topic.