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Genetic and Rare Diseases Information Center (GARD)

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Hypotrichosis simplex


Other Names for this Disease

  • Hereditary hypotrichosis simplex
  • HHS
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Overview

Hypotrichosis simplex is a rare form of hereditary hair loss without other abnormalities. Affected individuals typically show normal hair at birth, but experience hair loss and thinning of the hair shaft that starts during early childhood and progresses with age. Hypotrichosis simplex can be divided into 2 forms: the scalp-limited form and the generalized form, in which all body hair is affected. The progressive thinning of the hair shaft is a typical feature of androgenetic alopecia. Hypotrichosis simplex can be inherited either as an autosomal dominant or autosomal recessive trait. Some cases are caused by mutations in the APCDD1 gene on chromosome 18p11.[1] To date, there is no treatment for this condition.[2]
Last updated: 7/12/2011

References

  1. Hypotrichosis simplex, Generalized, Heriditary. Online Mendelian Inheritance in Man (OMIM). 2011; http://omim.org/entry/605389. Accessed 7/12/2011.
  2. Betz RC. Hypotrichosis simplex. Orphanet. 2010; http://www.orphanet.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=55654. Accessed 7/12/2011.
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In Depth Information

  • The Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine. 
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs.  Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Hypotrichosis simplex. Click on the link to view a sample search on this topic.
Other Names for this Disease
  • Hereditary hypotrichosis simplex
  • HHS
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.