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Genetic and Rare Diseases Information Center (GARD)

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Autoimmune progesterone dermatitis

Other Names for this Disease
  • APD
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How might autoimmune progesterone dermatitis be treated?

Evidence has shown that there are various possible treatments for autoimmune progesterone dermatitis (APD), depending on the symptoms and level of progesterone sensitivity that an affected woman has.[4862] Mild skin problems may improve with topical steroids for eczema, or oral antihistamines for urticaria, for example. However, the condition is sometimes resistent to this type of therapy. More severe skin problems may require treatment with systemic corticosteroids.[4856] Definitive treatment of APD involves agents that keep a woman from ovulating, thus suppressing the secretion of progesterone within the body.[4862] This may be accomplished with hormone-based therapy, which may involve the use of estrogen, estradiol, tamoxifen, and/or danazol. Medications containing any progesterone (such as oral contraceptives) should be avoided.[4856] In individuals for whom these treatments are ineffective, surgical removal of the ovaries (oophorectomy) has been shown to cure the condition.[4856] In a few cases, the condition resolves on its own without treatment or during pregnancy.[4855]
Last updated: 1/9/2012