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Genetic and Rare Diseases Information Center (GARD)

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Autoimmune progesterone dermatitis


Other Names for this Disease

  • APD
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Overview

Autoimmune progesterone dermatitis (APD) is a rare condition characterized by a cyclic skin rash which develops premenstrually in women. The condition usually occurs in adulthood after the start of periods (menarche), and rarely during pregnancy or postmenopause.[1] Signs and symptoms vary among affected individuals; skin findings that have been reported include hives, erythema multiforme, papulovesicles (an eczema-like rash), annular erythema, angiodema, mouth erosions and pruritus (itching).[1][2] The rash typically begins a few days before menses and subsides around the time menstruation begins, recurring at the next cycle.[2] The exact cause is unknown, but is thought to involve a hypersensitivity reaction to a woman's own progesterone.[3] Depending on the severity, treatment may include topical medications, systemic corticosteroids, hormone therapy to inhibit the production of progesterone, or surgical removal of the ovaries.[2]
Last updated: 1/9/2012

References

  1. TuEgba Oskay, Lale Kutluay, Asli Kaptanocglu, Onur Karabacak. Autoimmune progesterone dermatitis. European Journal of Dermatology. November-December 2002; 12(6):589-591.
  2. Autoimmune progesterone dermatitis. DermNet NZ. December 9, 2009; http://dermnetnz.org/reactions/progesterone-dermatitis.html. Accessed 1/6/2011.
  3. Tami Maguire. Autoimmune Progesterone Dermatitis. Dermatology Nursing. 2009; 21(4):190-192. http://www.medscape.com/viewarticle/712365. Accessed 1/9/2012.
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Basic Information

  • DermNet NZ is an online resource about skin diseases developed by the New Zealand Dermatological Society Incorporated. DermNet NZ provides information about this condition.

In Depth Information

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Other Names for this Disease
  • APD
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.