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Genetic and Rare Diseases Information Center (GARD)

Other Names for this Disease
  • Median fissure of nose
  • Nose, median cleft of
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A bifid nose is a relatively uncommon malformation that is characterized by the nose being divided into two parts. There is a large degree of variability in the severity of the condition, ranging from a minimally noticeable groove down the center of the nasal tip to a complete clefting of the underlying bones and cartilage, resulting in 2 complete half noses.[1][2] It is often associated with hypertelorbitism and midline clefts of the lip.[1] The airway usually is adequate despite the cosmetic appearance associated with the condition.[2] Both autosomal recessive and autosomal dominant inheritance of a bifid nose has been observed.[3] It may also occur with frontonasal dysplasia (a condition in with several possible findings limited to the head and neck), for which several inheritance patterns have been reported.[4] Treatment typically consists of surgical reconstruction to repair the malformation.[1]
Last updated: 7/1/2011


  1. Miller PJ, Grinberg D, Wang TD. Midline cleft. Treatment of the bifid nose. Archives of Facial Plastic Surgery. July-Sept 1999; Accessed 7/1/2011.
  2. Paul W. Flint et al. Cummings Otolaryngology: Head & Neck Surgery. 5th ed. USA: Mosby Elsevier; 2010;
  3. Victor A. McKusick. Bifid Nose, Autosomal Recessive. OMIM. 1986; Accessed 7/1/2011.
  4. Marla J. F. O'Neill . FRONTONASAL DYSPLASIA 1; FND1. OMIM. June 17, 2010; Accessed 7/1/2011.
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