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Genetic and Rare Diseases Information Center (GARD)

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Hemophilia B


Other Names for this Disease
  • Christmas disease
  • Factor IX deficiency
  • HEM B
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Overview


Hemophilia B is a bleeding disorder that slows the blood clotting process. People with this condition experience prolonged bleeding or oozing following an injury or surgery. In severe cases of hemophilia, heavy bleeding occurs after minor trauma or even in the absence of injury. Serious complications can result from bleeding into the joints, muscles, brain, or other internal organs. Milder forms may not become apparent until abnormal bleeding occurs following surgery or a serious injury. People with an unusual form of hemophilia B, known as hemophilia B Leyden, experience episodes of excessive bleeding in childhood but have few bleeding problems after puberty. Hemophilia B is inherited in an X-linked recessive pattern and is caused by mutations in the F9 gene.[1]
Last updated: 6/16/2011

References

  1. Hemophilia. Genetics Home Reference. May 2010; http://ghr.nlm.nih.gov/condition=hemophilia. Accessed 6/16/2011.
Your Questions Answered
by the Genetic and Rare Diseases Information Center

Please contact us with your questions about Hemophilia B. We will answer your question and update these pages with new resources and information.

Basic Information

  • The American Society of Gene & Cell Therapy provides information on the treatment of hemophilia.
  • Genetics Home Reference (GHR) contains information on Hemophilia B. This website is maintained by the National Library of Medicine.
  • MedlinePlus was designed by the National Library of Medicine to help you research your health questions, and it provides more information about this topic.
  • The Merck Manuals Online Medical Library provides information on this condition. Click on the link to view the information.
  • The National Human Genome Research Institute's (NHGRI) mission encompasses a broad range of studies aimed at understanding the structure and function of the human genome and its role in health and disease. Click on the link to view the information page on this topic.
  • The National Organization for Rare Disorders (NORD) is a federation of more than 130 nonprofit voluntary health organizations serving people with rare disorders. Click on the link to view information on this topic.

In Depth Information

  • The Online Mendelian Inheritance in Man (OMIM) is an catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine. 
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs.  Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Hemophilia B. Click on the link to view a sample search on this topic.