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Genetic and Rare Diseases Information Center (GARD)

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Klinefelter syndrome

Other Names for this Disease
  • Klinefelter's syndrome
  • XXY syndrome
Related Diseases
More Related Diseases
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Your Question

I was diagnosed with Klinefelter syndrome. I have been trying to lose some of the fat around my waist for years. Does Klinefelter syndrome cause weight gain or make it harder to lose weight?

Our Answer

We have identified the following information that we hope you find helpful. If you still have questions, please contact us.

Does Klinefelter syndrome cause weight gain or make it more difficult for a person to lose weight?

We were unable to locate specific information about whether there is a direct link between weight gain/loss and Klinefelter syndrome. However, there is evidence that hypogonadism, a very common feature of Klinefelter syndrome, has been found to increase the risk for the development of abdominal adiposity (obesity), even in men with normal chromosomes. Both hypogonadism (without Klinefelter syndrome) and Klinefelter syndrome have been found to be associated with an increased risk of type 2 diabetes.  The reason that Klinefelter syndrome is associated with an increased risk of diabetes has not been determined.[1]
Last updated: 9/18/2013