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Other Names for this Disease
- Immunodeficiency with thymoma
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Good syndrome is a rare, adult-onset primary immunodeficiency suspected in patients who exhibit hypogammaglobulinemia and low levels of B cells along with a benign thymic tumor (thymoma) on chest X-ray. Symptoms include frequent opportunistic infections involving the sinuses and lungs, including severe CMV disease, P. carinii pneumonia, and mucocutaneous candidiasis. While the cause of Good syndrome remains unknown, there is some evidence that a defect of the bone marrow is involved. Treatment includes removal of the thymic tumor and immunoglobulin replacement.
- Other Important Primary Immunodeficiency Diseases. Immune Deficiency Foundation. http://primaryimmune.org/about-primary-immunodeficiency-diseases/types-of-pidd/other-important-primary-immunodeficiency-diseases. Accessed December 6, 2011.
- Tarr PE, Sneller MC, Mechanic LJ, Economides A, Eger CM, Strober W, Cunningham-Rundles C, Lucey DR. Infections in patients with immunodeficiency with thymoma (Good syndrome). Report of 5 cases and review of the literature. Medicine (Baltimore). 2001. http://www.ncbi.nlm.nih.gov/pubmed/11307588. Accessed December 6, 2011.
- P Kelleher, SA Misbah. What is Good’s syndrome? Immunological abnormalities in patients with thymoma. J Clin Pathol . 2003. http://jcp.bmj.com/content/56/1/12.full. Accessed December 6, 2011.
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