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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Systemic mastocytosis


Other Names for this Disease

  • Agressive systemic mastocytosis
  • Indolent systemic mastocytosis
  • Mast cell leukemia
  • SMCD
  • Systemic mast cell disease
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Treatment

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How might systemic mastocytosis be treated?

Treatment for systemic mastocytosis is based on each individual's symptoms. This includes efforts to control anaphylaxis and other allergic reactions, itching (pruritus) and flushing, and intestinal malabsorption.[1]  Some of the  medications used to treat systemic mastocytosis include:[2]


  • Antihistamines to treat itching, other skin complaints, severe flushing and low blood pressure before symptoms appear, and ulcers;
  • Proton pump inhibitors to relieve ulcer-like symptoms;
  • Epinephrine to treat symptom flares which occur with shock, referred to as anaphylaxis;
  • Steroids to treat malabsorption (impaired ability to take in nutrients); and  
  • Cromolyn sodium which may help reduce cramping in the abdomen.

In cases in which mastocytosis is malignant, cancerous, or associated with a blood disorder, steroids and/or chemotherapy may be necessary.[2]

More specific information about treatment options can be accessed through the Treatment and Medication sections of the Medscape Reference web site.

Last updated: 10/5/2012

References
  1. Krishnan K, Jaishankar D. Systemic Mastocytosis Treatment & Management. Medscape Reference. February 2012; http://emedicine.medscape.com/article/203948-treatment#showall. Accessed 10/5/2012.
  2. Mastocytosis: Treatment. National Institute of Allergy and Infectious Diseases (NIAID). January 2011; http://www.niaid.nih.gov/topics/mastocytosis/Pages/Treatment.aspx. Accessed 10/5/2012.


Clinical Trials & Research for this Disease

  • ClinicalTrials.gov lists trials that are studying or have studied Systemic mastocytosis. Click on the link to go to ClinicalTrials.gov to read descriptions of these studies.
Other Names for this Disease
  • Agressive systemic mastocytosis
  • Indolent systemic mastocytosis
  • Mast cell leukemia
  • SMCD
  • Systemic mast cell disease
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.