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Harlequin syndrome

Other Names for this Disease
  • Sudden onset of unilateral flushing and sweating
  • Unilateral loss of facial flushing and sweating with contralateral anhidrosis
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Harlequin syndrome was first coined by Lance and Drummond in 1988 when they described five cases of unilateral (on one side) flushing and sweating.[1] The asymmetrical facial sweating and flushing described with this condition has been named the 'Harlequin Sign'.
Last updated: 6/29/2009


  1. Corbett M, Abernethy DA. Harlequin syndrome. J Neurol Neurosurg Psychiatry. 1999; Accessed 6/29/2009.
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