Your browser does not support javascript:   Search for gard hereSearch for news-and-events here.


Genetic and Rare Diseases Information Center (GARD)

Print friendly version

Morgagni-Stewart-Morel syndrome

Other Names for this Disease
  • Hyperostosis frontalis interna, obesity, shortness and cognitive impairment
  • MSM syndrome
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Your Question

It is my understanding that hyperostosis frontalis interna can be a symptom of Morgagni-Stewart-Morel syndrome. What medical tests would you normally use to identify this condition? What are the symptoms of this condition? Is there any treatment, especially for the headaches associated with this condition?

Our Answer

We have identified the following information that we hope you find helpful. If you still have questions, please contact us.

What are the signs and symptoms of Morgagni-Stewart-Morel syndrome?

The signs and symptoms of Morgagni-Stewart-Morel (MSM) syndrome typically include the characteristic X-ray finding of thickening of the frontal bone of the skull (hyperostosis frontalis interna) and may also include headache, vertigo, hirsutism, menstrual disorders, galactorrhea, obesity, depression, irritability, fatigability, temporary paralysis on one side of the body, hearing impairment, paralysis of the cranial nerves, muscle weakness, and seizures.[1]
Last updated: 3/28/2011

How might Morgagni-Stewart-Morel syndrome be diagnosed?

The diagnosis of Morgagni-Stewart-Morel syndrome is based upon a radiological finding of hyperostosis frontalis interna, as well as a combination of clinical features including obesity, virulism, possible mental disturbance, and other findings.[2][3]
Last updated: 3/25/2011

How might hyperostosis frontalis interna be treated?

Unfortunately, there is currently no known standard treatment for hyperostosis frontalis interna (HFI). Seizures and headaches that may be associated with HFI are typically treated with standard medications.[4]

There is little published, accessible information regarding treatment options for HFI. In one journal article, the authors discuss an individual with Morgagni-Stewart-Morel syndrome who reportedly had violent headaches. They stated that surgery was performed to remove the hypertrophic frontal bone, followed by dura and bone reconstruction. The authors stated that the pains ceased immediately after the operation. They further discuss surgical treatment, especially in cases with high intensity headaches.[5]
Last updated: 3/28/2011