Your browser does not support javascript:   Search for gard hereSearch for news-and-events here.

Diseases

Genetic and Rare Diseases Information Center (GARD)

Print friendly version

Balkan endemic nephropathy


Other Names for this Disease

  • AAN
  • Aristolochic acid nephropathy
  • BEN
  • Danubian endemic familial nephropathy
  • DEFN
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Overview

Balkan endemic nephropathy is a kidney disease that affects people living in rural areas of Bosnia, Bulgaria, Croatia, Romania, and Serbia. Affected individuals develop kidney damage that progresses to kidney failure. Many people with this condition also develop a type of bladder cancer known as upper urothelial carcinoma (UUC) or transitional cell carcinoma. Balkan endemic nephropathy is caused by eating bread that is contaminated with a toxin called aristolochic acid, which comes from a plant called Aristolochia. Balkan endemic nephropathy can occur in multiple family members, but it is not an inherited condition.[1]
Last updated: 4/4/2011

References

  1. Grollman AP, Shibutani S, Moriya M, Miller F, Wu L, Moll U, et al. Aristolochic acid and the etiology of endemic (Balkan) nephropathy. Proc Natl Acad Sci USA. 2007 Jul 17; 104(29):12129-34. http://www.pnas.org/content/104/29/12129.long. Accessed 4/4/2011.
Your Questions Answered
by the Genetic and Rare Diseases Information Center

Please contact us with your questions about Balkan endemic nephropathy. We will answer your question and update these pages with new resources and information.

In Depth Information

  • The Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine.¬†
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Balkan endemic nephropathy. Click on the link to view a sample search on this topic.

Selected Full-Text Journal Articles

  • Grollman AP, Shibutani S, Moriya M, Miller F, Wu L, Moll U, et al.¬†Aristolochic acid and the etiology of endemic (Balkan) nephropathy. Proc Natl Acad Sci USA. 2007 Jul 17;104(29):12129-34. Available at: http://www.pnas.org/content/104/29/12129.long.
Other Names for this Disease
  • AAN
  • Aristolochic acid nephropathy
  • BEN
  • Danubian endemic familial nephropathy
  • DEFN
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.