Your browser does not support javascript:   Search for gard hereSearch for news-and-events here.

Diseases

Genetic and Rare Diseases Information Center (GARD)

Print friendly version

Intervertebral disc disease

*

* Not a rare disease

Other Names for this Disease

  • Degenerative disc disease
  • IDD
  • Intervertebral disc degeneration
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Cause

Newline Maker

What causes intervertebral disc disease?

Intervertebral disc disease (IDD) is a multifactorial disorder, which means that both genetic and environmental factors probably interact to predispose an individual to the condition. It is likely that several factors are needed for development of IDD. Factors such as occupational stress, trauma, or obesity, together with genetic alterations, may result in the structural weakness of a disc, cause a herniation, and possibly initiate a cascade of events leading to sciatica and pathological disc changes.[1] One of the best-known environmental risk factors for IDD is vibration in occupational driving.[2] Inflammation is also likely to play an important role in the progression of this process.[1]
Last updated: 3/12/2012

References
  1. Noponen-Hietala N. et al. Genetic variations in IL6 associate with intervertebral disc disease characterized by sciatica. Pain. March 2005; 114(1-2):186-194.
  2. Virtanen IM et al. Occupational and genetic risk factors associated with intervertebral disc disease. Spine (Phila Pa 1976). May 1, 2007; 32(10):1129-1134.


Other Names for this Disease
  • Degenerative disc disease
  • IDD
  • Intervertebral disc degeneration
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.