Other Names for this Disease
- Hashimoto's encephalopathy
- Steroid-responsive encephalopathy associated with autoimmune thyroiditis
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Medical management of Hashimoto's encephalitis (HE) usually involves corticosteroids and treatment of thyroid abnormalities and seizures (if present). The optimal dose of oral steroids is not known, but in general may range from 50 mg/day to 150 mg/day. Decisions regarding the length of steroid treatment and rate of tapering off steroids are based on the individual's response to treatment. Most people with HE improve or fully recover with steroid therapy, typically within a few months. Some people require prolonged steroid treatment. Recurrences typically respond to steroid treatment.
People with HE who experience repeated HE relapses, do not respond to steroids, and/or cannot tolerate steroid treatment have been treated with immunosuppressive medications (e.g., azathioprine and cyclophosphamide), immunosuppressive and steroid combination therapy, intravenous immunoglobulin, or plasmapheresis. Due to the rarity of these cases, data regarding treatment effectiveness is lacking.
- Rubin D. Hashimoto's encephalopathy. In: Basow. UpToDate. Waltham, MA: UpToDate; 2013;
- Marshall GA, Doyle JJ. J Neuropsychiatry Clin Neurosci. 2006; http://neuro.psychiatryonline.org/cgi/content/full/18/1/14. Accessed 4/16/2010.