Your browser does not support javascript:   Search for gard hereSearch for news-and-events here.


Genetic and Rare Diseases Information Center (GARD)

Print friendly version

Hashimoto's encephalitis

Other Names for this Disease
  • Hashimoto's encephalopathy
  • Steroid-responsive encephalopathy associated with autoimmune thyroiditis
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.


Newline Maker

How might Hashimoto's encephalitis be treated?

Medical management of Hashimoto's encephalitis (HE) usually involves corticosteroids and treatment of thyroid abnormalities and seizures (if present). The optimal dose of oral steroids is not known, but in general may range from 50 mg/day to 150 mg/day. Decisions regarding the length of steroid treatment and rate of tapering off steroids are based on the individual's response to treatment. Most people with HE improve or fully recover with steroid therapy, typically within a few months. Some people require prolonged steroid treatment.[1] Recurrences typically respond to steroid treatment.[2]

People with HE who experience repeated HE relapses, do not respond to steroids, and/or cannot tolerate steroid treatment have been treated with immunosuppressive medications (e.g., azathioprine and cyclophosphamide), immunosuppressive and steroid combination therapy, intravenous immunoglobulin, or plasmapheresis.[2][1] Due to the rarity of these cases, data regarding treatment effectiveness is lacking.

Last updated: 5/6/2013

  1. Rubin D. Hashimoto's encephalopathy. In: Basow. UpToDate. Waltham, MA: UpToDate; 2013;
  2. Marshall GA, Doyle JJ. J Neuropsychiatry Clin Neurosci. 2006; Accessed 4/16/2010.