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Moebius syndrome

Other Names for this Disease
  • Absence or underdevelopment of the 6th and 7th cranial nerves
  • Congenital facial diplegia
  • Congenital facial diplegia syndrome
  • Congenital oculofacial paralysis
  • MBS
More Names
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What is Moebius syndrome?

Is Moebius syndrome inherited?

What is Moebius syndrome?

Moebius syndrome is a rare neurological condition that primarily affects the muscles that control facial expression and eye movement. Signs and symptoms of the condition may include weakness or paralysis of the facial muscles; feeding, swallowing, and choking problems; excessive drooling; crossed eyes; lack of facial expression; eye sensitivity; high or cleft palate; hearing problems; dental abnormalities; bone abnormalities in the hands and feet; and/or speech difficulties.[1][2] Affected children often experience delayed development of motor skills (such as crawling and walking), although most eventually acquire these skills.[1] Moebius syndrome is caused by the absence or underdevelopment of the 6th and 7th cranial nerves, which control eye movement and facial expression. Other cranial nerves may also be affected.[2] There is no cure for Moebius syndrome, but proper care and treatment give many individuals a normal life expectancy.[2]
Last updated: 7/15/2013

Is Moebius syndrome inherited?

Most cases of Moebius syndrome are not inherited and occur as isolated cases in individuals with no history of the condition in their family (sporadically). A small percentage of cases of Moebius syndrome have been familial (occurring in more than one individual in a family), but a there has not been a consistent pattern of inheritance among all affected families.[3][4] In some families the pattern has been suggestive of autosomal dominant inheritance, while in other families it has been suggestive of autosomal recessive or X-linked recessive inheritance.[4]
Last updated: 7/15/2013

  1. Moebius syndrome. Genetics Home Reference. July 2010; Accessed 3/11/2011.
  2. NINDS Moebius Syndrome Information Page. National Institute of Neurological Disorders and Stroke, National Institutes of Health. September 16, 2008; Accessed 3/11/2011.
  3. Moebius syndrome. Genetics Home Reference. July 2010; Accessed 7/15/2013.
  4. Marla J. F. O'Neill. MOEBIUS SYNDROME; MBS. OMIM. July 26, 2012; Accessed 7/15/2013.