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Genetic and Rare Diseases Information Center (GARD)

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HELLP syndrome

Other Names for this Disease
  • Hemolysis, Elevated Liver Enzymes, Lowered Platelets
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Your Question

Can the symptoms of HELLP syndrome be caused by a vitamin B12 deficiency?

Our Answer

We have identified the following information that we hope you find helpful. If you still have questions, please contact us.

Can the symptoms of HELLP syndrome be caused by a vitamin B12 deficiency?

Although vitamin B12 deficiency is not typically included in the differential diagnosis for HELLP syndrome, there are overlapping features for both conditions. We identified the following reports of suspected HELLP syndrome that were due to deficiency of Vitamin B12. 

Chauvet E, Youssef M, Boukhari R, El Guindi W, Carles G. [Symptoms of HELLP syndrome due to vitamin B12 deficiency: report of seven cases]. J Gynecol Obstet Biol Reprod (Paris). 2009 May;38(3):226-30. Article in French.

Hartong SC, Steegers EA, Visser W. Hemolysis, elevated liver enzymes and low platelets during pregnancy due to Vitamin B12 and folate deficiencies. Eur J Obstet Gynecol Reprod Biol. 2007 Apr;131(2):241-2.

You can find additional articles on the association between HELLP syndrome and B12 deficiency through PubMed, a searchable database of biomedical journal articles. Although not all of the articles are available for free online, most articles listed in PubMed have a summary available. To obtain the full article, contact a medical/university library or your local library for interlibrary loan. You can also order articles online through the publisher’s Web site.

The National Library of Medicine (NLM) Web site has a page for locating libraries in your area that can provide direct access to these journals (print or online). The Web page also describes how you can get these articles through interlibrary loan and Loansome Doc (an NLM document-ordering service). You can access this page at the following link You can also contact the NLM toll-free at 888-346-3656 to locate libraries in your area.

Last updated: 5/1/2013