Print friendly version
Other Names for this Disease
- Diaphyseal sclerosis, multiple
- Hereditary multiple diaphyseal sclerosis
- Multiple diaphyseal sclerosis
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.
 Ribbing disease affects women more frequently than men. The most common symptom is pain. A single study of 14 patients found an association between Ribbing disease and impaired exercise tolerance and changes in heart function (i.e., increased prevalence of arrhythmia and changes in left ventricular systolic and diastolic function). The cause of the condition is currently unknown, although some cases appear to be genetic and inherited in an autosomal recessive fashion. Optimal treatment for the disease is largely unknown. There have been case reports describing treatment of Ribbing disease with bisphosphonate pamidronate. Results have been mixed. The condition often resolves on its own; however cases of progressive disease have been described.Ribbing disease is a rare bone disease that causes bony growths on the long bones, such as the thigh bone and shine bone.
Last updated: 12/1/2011
- Ziran, et. al.. Ribbing disease: radiographic and biochemical characterization, lack of response to pamidronate. Skeletal Radiol. 2002; 12:714-719. http://www.ncbi.nlm.nih.gov/pubmed/12483434. Accessed 12/1/2011.
- Rubin, et. al.. Clinical, humoral and scintigraphic assessment of a bisphosphonate as potential treatment of diaphyseal dysplasia: Ribbing and Cammurati-Engelmann diseases. Medicina (B. Aires). 1997; http://www.ncbi.nlm.nih.gov/pubmed/9567356. Accessed 4/15/2011.
- Ribbing disease. Online Mendelian Inheritance in Man (OMIM). June 2009; http://www.ncbi.nlm.nih.gov/omim/601477. Accessed 12/1/2011.
- Cocco G, Kovac C, Sfrisi C, Pouleur H. Cardiac involvement in Ribbing's disease. Eur Heart J. 1994; 15(8):1124-8. http://eurheartj.oxfordjournals.org/content/15/8/1124.short. Accessed 12/1/2011.
Your Questions Answeredby the Genetic and Rare Diseases Information Center
Please contact us with your questions about Ribbing disease. We will answer your question and update these pages with new resources and information.
On this page
In Depth Information
- The Online Mendelian Inheritance in Man (OMIM) database contains genetics resources that discuss Ribbing disease. Click on the link to go to OMIM and review these resources.
- PubMed is a searchable database of medical literature and lists journal articles that discuss Ribbing disease. Click on the link to view a sample search on this topic.