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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Muckle-Wells syndrome


Other Names for this Disease
  • Muckle Wells syndrome
  • UDA syndrome
  • Urticaria, deafness and amyloidosis
  • Urticaria-deafness-amyloidosis syndrome
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Your Question

Is Muckle-Wells Syndrome life threatening?

Our Answer

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Is Muckle-Wells Syndrome life threatening?

Muckle-Wells syndrome can have severe consequences as a result of long-term high levels of inflammation in the body.[1] In some patients, this leads to secondary or AA amyloidosis, an abnormal accumulation of the protein amyloid in the tissues and organs. This can become life-threatening due to a permanent build-up of amyloid in the kidneys, liver, spleen, and elsewhere.[1][2] The most common clinical presentation is kidney failure.[2] 
Last updated: 10/17/2011

References