Your browser does not support javascript:   Search for gard hereSearch for news-and-events here.


Genetic and Rare Diseases Information Center (GARD)

Print friendly version

Muckle-Wells syndrome

Other Names for this Disease
  • Muckle Wells syndrome
  • UDA syndrome
  • Urticaria, deafness and amyloidosis
  • Urticaria-deafness-amyloidosis syndrome
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Your Question

Is Muckle-Wells Syndrome life threatening?

Our Answer

We have identified the following information that we hope you find helpful. If you still have questions, please contact us.

Is Muckle-Wells Syndrome life threatening?

Muckle-Wells syndrome can have severe consequences as a result of long-term high levels of inflammation in the body.[1] In some patients, this leads to secondary or AA amyloidosis, an abnormal accumulation of the protein amyloid in the tissues and organs. This can become life-threatening due to a permanent build-up of amyloid in the kidneys, liver, spleen, and elsewhere.[1][2] The most common clinical presentation is kidney failure.[2] 
Last updated: 10/17/2011