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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Fibrosing mediastinitis


Other Names for this Disease
  • Idiopathic mediastinal fibrosis
  • Mediastinal fibrosis
  • Sclerosing mediastinitis
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Symptoms


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What are the signs and symptoms of fibrosing mediastinitis?

Early signs and symptoms of fibrosing mediastinits relate to blockages of structures in the mediastinum (e.g., superior vena cava, central pulmonary veins) which can cause a narrowing of the airways or may entrap or block blood vessels. Signs and symptoms include:[1][2][3][4]

Cough
Shortness of breath
Recurrent lung infection
Hemoptysis
Pleuritic chest pain

Occasionally people with fibrosing mediastinitis present with fever and weight loss.[1]

Fibrosing mediastinits can cause serious health complications, particularly in people who experience recurrent infection, hemoptysis, or cor pulmonale. People with fibrosing mediastinitis involving the space below the trachea or involving both sides of the mediastinum may be at a higher risk for serious complications than are people with more localized disease.[1]

Last updated: 4/23/2010

References
  1. Rossi S, McAdams H, Rosado-de-Christenson M, Franks T, Galvin J. Fibrosing Mediastinitis. Radiographics. 2001;
  2. Chiller T. Chapter 5: Other infectious diseases related to travel. Centers for Disease Control and Prevention. 2009; http://wwwnc.ced.gov/travel/yellowbook/2010/chapter-5/histoplasmosis.aspx. Accessed 4/22/2010.
  3. MacDonald S, Padley S. The mediastinum, including the pericardium. In: Adam A, Dixon AK. Grainger & Allison’s Diagnostic Radiology, 5th ed. Philadelphia, PA: Churchill Livingston; 2008;
  4. Worrell JA, Donnelly EF, Martin JB, Bastarache JA, Loyd JE. Computed tomography and the idiopathic form of proliferative fibrosing mediastinits. J Thorac Imaging. 2007;