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Genetic and Rare Diseases Information Center (GARD)

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Swyer-James syndrome

Other Names for this Disease
  • Swyer-James-MacLeod syndrome
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Swyer-James syndrome is a rare condition in which the lung (or portion of the lung) does not grow normally and is slightly smaller than the opposite lung, usually following bronchiolitis in childhood. It is typically diagnosed after a chest X-ray or CT scan which shows unilateral pulmonary hyperlucency (one lung appearing less dense) and diminished pulmonary arteries.[1][2] Affected individuals may not have any symptoms, or more commonly, they may have recurrent pulmonary infections and common respiratory symptoms.[2] The cause of the condition is not completely understood.
Last updated: 10/21/2011


  1. Beverly P Wood. Swyer-James Syndrome Imaging . eMedicine. May 25, 2011; Accessed 10/19/2011.
  2. Bai Chong, Song Xiao-lian, Shi Hui, Yao Xiao-Peng and Li Qiang. Swyer-James Syndrome with Peculiar Course and Ipsilateral Pulmonary Vein Defect. Internal Medicine. 2011; 50:1829-1833.
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