Your browser does not support javascript:   Search for gard hereSearch for news-and-events here.


Genetic and Rare Diseases Information Center (GARD)

Print friendly version

Punctate porokeratosis

Other Names for this Disease
  • Porokeratosis punctata palmaris et plantaris
  • PPPP
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Your Question

My biopsy report showed that I have porokeratosis punctata on my foot.  I have been unable to find much information on this diagnosis.  Can this lead to a pre-cancerous condition?

Our Answer

We have identified the following information that we hope you find helpful. If you still have questions, please contact us.

What is punctate porokeratosis?

Punctate porokeratosis is a skin condition that appears in adulthood as many, tiny, ridgelike bumps on the palms of the hands and soles of the feet.  These bumps may slowly spread over the skin and usually do not cause symptoms, though they sometimes cause itching or discomfort while walking.  Individuals with this condition often develop other types of porokeratosis as well.  The cause of punctate porokeratosis is unknown, though genetic factors, a weakened immune system (immunodeficiency), or previous injury to the skin (for example, a burn) have been suggested as possible risk factors.   Treatment depends on the size, location, and aggressiveness of porokeratosis in each affected individual; it may include observation only, medication, or surgery.[1]
Last updated: 8/24/2012

Can punctate porokeratosis give rise to cancer?

On average, approximately 8% of individuals with porokeratosis may develop a skin cancer.  Though all types of porokeratosis are thought to increase the chance to develop skin cancer, punctate porokeratosis is thought to have the lowest risk of the group.  The chance of porokeratosis becoming cancerous is increased if the affected area is large, located on the limbs, or has been present for a long time.[2]
Last updated: 8/24/2012

How might punctate porokeratosis be treated?

Treatment depends on the size, location, and aggressiveness of punctate porokeratosis.  Affected individuals are recommended to visit their personal physician regularly to watch for signs of skin cancer, limit sun exposure to the affected area, and use moisturizers as needed.[3]  5-fluorouracil cream has been found to be an effective treatment.  A group of medications called retinoids (including acitretin and isotretinoin), as a pill or cream, may be another treatment option.[3]  If a skin cancer develops from porokeratosis, surgery is recommended.[1]
Last updated: 8/24/2012