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Genetic and Rare Diseases Information Center (GARD)

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Sclerosing mesenteritis

Other Names for this Disease
  • Idiopathic sclerosing mesenteritis
  • Liposclerotic mesenteritis
  • Mesenteric fibromatosis
  • Mesenteric lipodystrophy
  • Mesenteric lipogranuloma
More Names
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How might sclerosing mesenteritis be treated?

Treatment for sclerosing mesenteritis is most often based on the stage of the disease.

  • In the early stage when fat necrosis predominates, many physicians tend not to treat because the disease process may regress spontaneously.[1]
  • When chronic inflammation becomes a prominent feature but fibrosis is not yet fully developed, medical treatment with corticosteroids, colchicine, immunosuppressants, or orally administered progesterone may be beneficial in the prevention of disease progression.[2][1] These medications are only given for a short period since they can cause serious side effects. Some studies have shown that patients with sclerosing mesenteritis may benefit from a drug combination of tamoxifen and prednisone.[2]
  • When fibrosis becomes extensive, especially when the disease presents as a large fibrotic mass with bowel obstruction, surgical interventions may be necessary.[2][1]
Last updated: 8/22/2011

  1. Sclerosing Mesenteritis. The Doctor's Doctor Web site. 2002; Accessed 7/11/2011.
  2. Sclerosing mesenteritis. . Accessed 7/11/2011.