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Genetic and Rare Diseases Information Center (GARD)

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Whipple disease


Other Names for this Disease

  • Intestinal lipodystrophy
  • Intestinal lipophagic granulomatosis
  • Secondary Non-tropical Sprue
  • Tropheryma whippelii infection
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Overview

Whipple disease is a multi-system infectious bacterial disease that interferes with the body's ability to metabolize fats.[1] The disorder usually occurs in the gastrointestinal system, but may affect any part of the body including the heart, lungs, brain, joints, and eyes.[2] In the gastrointestinal system it interferes with the body's ability to absorb certain nutrients.[2][3] This leads to a condition known as malabsorption.[3] Whipple disease causes weight loss, incomplete breakdown of carbohydrates or fats, and malfunctions of the immune system.[2] It is caused by infection from bacteria called Tropheryma whippelii.[2][3] When recognized and treated, Whipple disease can usually be cured. Untreated, the disease may be fatal.[2]
Last updated: 8/1/2012

References

  1. NINDS Whipple's Disease Information Page. National Institute of Neurological Disorders and Stroke (NINDS). March 22, 2011; http://www.ninds.nih.gov/disorders/whipples/whipples.htm. Accessed 8/1/2012.
  2. Whipple's Disease. National Digestive Diseases Information Clearinghouse (NDDIC). April 30, 2012; http://digestive.niddk.nih.gov/ddiseases/pubs/whipple/index.htm. Accessed 8/1/2012.
  3. Dugdale DC, Longstreth GF. Whipple's disease. MedlinePlus. May 1, 2012; http://www.nlm.nih.gov/medlineplus/ency/article/000209.htm. Accessed 8/1/2012.
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Basic Information

  • MedlinePlus was designed by the National Library of Medicine to help you research your health questions, and it┬áprovides more information about this topic.
  • The National Digestive Diseases Information Clearinghouse (NDDIC), part of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), offers information on this condition. Click on the link to view information on this topic.
  • The National Institute of Neurological Disorders and Stroke (NINDS) collects and disseminates research information related to neurological disorders. Click on the link to view information on┬áthis topic.
  • The National Organization for Rare Disorders (NORD) is a federation of more than 130 nonprofit voluntary health organizations serving people with rare disorders. Click on the link to view information on this topic.

In Depth Information

  • Medscape Reference provides information on this topic. Click on the link to view this information. You may need to register to view the medical textbook, but registration is free.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Whipple disease. Click on the link to view a sample search on this topic.
Other Names for this Disease
  • Intestinal lipodystrophy
  • Intestinal lipophagic granulomatosis
  • Secondary Non-tropical Sprue
  • Tropheryma whippelii infection
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.