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Warm antibody hemolytic anemia

Other Names for this Disease
  • Warm antibody AIHA
  • Warm antibody autoimmune hemolytic anemia
  • Warm-reacting-antibody hemolytic anemia
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Warm antibody hemolytic anemia is the most common form of autoimmune hemolytic anemia. It is defined by the presence of  autoantibodies that attach to and destroy red blood cells at temperatures equal to or greater than normal body temperature.[1][2] The disease is characterized by symptoms related to anemia, including fatigue, difficulty breathing, jaundice and dark urine. In severe disease, fever, chest pain, syncope or heart failure may occur. Hemolysis (the breakdown of red blood cells) occurs mainly in the spleen, so mild splenomegaly is relatively common. Treatment typically involves a corticosteroid like prednisone. In cases that don't respond to treatment, splenectomy may be considered. Chronic and severe disease may be treated with Rituximab or immunosuppressive medications. [2] 
Last updated: 12/19/2012


  1. Lichtin AE. Autoimmune Hemolytic Anemia. Merck Manual. June 2008; Accessed 12/19/2012.
  2. Michel M. Autoimmune hemolytic anemia, warm type. Orphanet. August 2012; Accessed 12/19/2012.
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