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Genetic and Rare Diseases Information Center (GARD)

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Waldenstrom macroglobulinemia

Other Names for this Disease
  • Lymphoplasmacytic lymphoma
  • Macroglobulinemia of Waldenstrom
  • Waldenstrom's macroglobulinaemia
  • Waldenstrom's syndrome
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How might Waldenstrom macroglobulinemia be treated?

For individuals who do not have any symptoms, doctors may decide to "watch and wait" and not treat the disease right away. This can last many years for some individuals. For individuals requiring treatment, the type and severity of symptoms present, aggressiveness of the disease, and age all play a role in the type of therapy chosen.[1][2]

Some affected individuals have a procedure called plasmapheresis, to reverse or prevent the symptoms associated with the thickening of the blood (hyperviscosity). This involves removing the blood, passing it through a machine that removes the part of the blood with the IgM antibody, and returning the blood to the body. This may be combined with other treatments such as various types of chemotherapy. Many different drugs can be used to manage this condition, both alone and/or in various combinations.

For many individuals, there is a delayed response to treatment and the best response sometimes occurs several months after the treatment ends. Although the condition is not curable, many individuals do have a long-term response to treatment. Those who relapse after treatment or do not respond to initial treatment may consider secondary therapies. There are also several new drugs and drug combinations that are being studied in clinical trials.[1]

More detailed information about the specific medications used to treat Waldenstrom macroglobulinemia can be viewed on Medscape Reference's Web site.
Last updated: 10/1/2013

  1. Waldenström's Macroglobulinemia. Lymphoma Research Foundation. 2012; Accessed 10/1/2013.
  2. Karen Seiter. Waldenstrom Macroglobulinemia. Medscape Reference. January 31, 2012; Accessed 10/1/2013.

Clinical Trials & Research for this Disease

  • The Centers for Mendelian Genomics program is working to discover the causes of rare genetic disorders. For more information about applying to the research study, please visit their website.
  • lists trials that are studying or have studied Waldenstrom macroglobulinemia. Click on the link to go to to read descriptions of these studies.