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Genetic and Rare Diseases Information Center (GARD)

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Vogt-Koyanagi-Harada syndrome

Other Names for this Disease
  • VKH syndrome
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What causes Vogt-Koyanagi-Harada syndrome?

Research has indicated that Vogt-Koyanagi-Harada syndrome is an autoimmune disease in which the body attacks its own pigment cells (melanocytes), possibly in response to an infection (ie: a virus).[1] The strong association between Vogt- Koyanagi-Harada syndrome and certain racial and ethnic groups suggests that genetic factors may be involved.  Genes related to the immune system, namely those genes in the HLA gene family, may play a role in the development of Vogt-Koyanagi-Harada syndrome.  [2]
Last updated: 3/14/2014

  1. Fang W, Yang P.. Vogt-Koyanagi-Harada. Current Eye Research. May, 2008; Accessed 10/28/2010.
  2. Walton RC.. Vogt-Koyanagi-Harada Disease. Emedicine. April 14, 2010; Accessed 10/28/2010.