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Genetic and Rare Diseases Information Center (GARD)

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Sezary syndrome

Other Names for this Disease
  • Sézary syndrome
  • Sezary's lymphoma
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Is Sezary syndrome inherited?

To our knowledge, there have not been any reports of familial cases of Sezary syndrome (e.g. the condition occurring in more than one member of a family), and the exact cause of the condition is currently unknown.[1]

A closely related condtion, mycosis fungoides (MF), has been reported to occur in more than one family member in several families.[1] Sezary syndrome has been considered a "leukemic variant" of MF in the past.[2] However, although there are conflicting reports in the literature, they are now more commonly thought to be separate conditions.
Last updated: 2/27/2013

  1. Hodak E. et al. Familial mycosis fungoides: report of 6 kindreds and a study of the HLA system. J Am Acad Dermatol. March 2005; 52(3 Pt 1):393-402.
  2. Cutaneous T-Cell Lymphomas. NORD. January 3, 2007; Accessed 4/30/2012.