Your browser does not support javascript:   Search for gard hereSearch for news-and-events here.


Genetic and Rare Diseases Information Center (GARD)

Print friendly version

Sezary syndrome

Other Names for this Disease
  • Sézary syndrome
  • Sezary's lymphoma
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.


Newline Maker

What causes Sezary syndrome?

Although several possible underlying causes of Sezary syndrome have been proposed, the exact cause remains unknown. Current research suggests that abnormalities of DNA are the underlying basis for cells becoming malignant (cancerous) in cutaneous T-cell lymphomas and other cancers. Although in some cases a predisposition to cancer may be inherited, most cancers result from abnormal genetic changes that occur spontaneously, possibly due to various environmental factors.[1] Some researchers have suggested that skin-associated microbes such as  Staphylococcus aureus and Chlamydia spp may play a role in antigen stimulation of T-cells, but definitive data has been very limited. Others have made associations between Sezary syndrome and cytomegalovirus and Epstein-Barr virus. More research regarding the potential causes of Sezary syndrome is needed and is currently under way.[2]
Last updated: 4/30/2012

  1. Cutaneous T-Cell Lymphomas. NORD. January 3, 2007; Accessed 4/30/2012.
  2. Hwang ST, Janik JE, Jaffe ES, Wilson WH. Mycosis fungoides and Sézary syndrome. Lancet. March 15, 2008; 371(9616):945-957.