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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Scleromyxedema


Other Names for this Disease

  • Arndt-Gottron disease
  • Generalized lichenoid papular eruption
  • Generalized papular and sclerodermoid
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Symptoms

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What are the signs and symptoms of scleromyxedema?

Scleromyxedema usually affects people between the ages of 30 and 50.[1] Skin symptoms usually include a generalized papular eruption with sclerosis (hardening of tissue). 

The papules may be dome shaped, firm, skin colored, or red, and approximately 3 mm in diameter.  Extensive areas of the skin may be involved. The face, knees, and elbows are often affected.

Scleromyxedema can involve areas of the body other than the skin, including the pharynx and the upper airway. Other symptoms that can be caused by scleromyxedema include:
  • Esophageal aperistalsis (absence of muscular contractions that help us swallow)  
  • Hoarseness  
  • Inflammatory polyarthritis (simultaneous inflammation of several joints) 
  • Proximal myopathy (various conditions or diseases of the muscular tissues) 
  • Neurologic dysfunction 
  • Eye abnormalities
Last updated: 1/6/2009

References
  1. Liotta E.A. Lichen Myxedematosus. eMedicine. 2006; http://www.emedicine.com/DERM/topic231.htm. Accessed 1/5/2009.


Other Names for this Disease
  • Arndt-Gottron disease
  • Generalized lichenoid papular eruption
  • Generalized papular and sclerodermoid
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.