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Genetic and Rare Diseases Information Center (GARD)

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Prune belly syndrome


Other Names for this Disease

  • Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism
  • Eagle-Barrett syndrome
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Overview

Prune belly syndrome, also called Eagle-Barrett syndrome, is a condition characterized by three main features: (1) a lack of abdominal muscles, causing the skin on the belly area to wrinkle and appear "prune-like";  (2) undescended testicles in males; and (3) urinary tract problems. The incidence of prune belly syndrome (PBS) is 1 in 40,000 births; 95% of cases occur in boys. The severity of symptoms in infants with prune belly syndrome can vary greatly from child to child.  At one end of the spectrum, the condition may cause severe urogenital and pulmonary problems incompatible with life (resulting in stillbirth); at the other end of the spectrum, the condition may cause few, if any, urological abnormalities that require no treatment other than  undescended testicle repair in males. The cause of the condition is unknown.[1][2]
Last updated: 5/18/2009

References

  1. BP Wood. Prune belly syndrome. eMedicine. 2008; http://www.emedicine.com/Radio/topic575.htm. Accessed 12/9/2008.
  2. Caldamone AA, Woodard JR. Prune belly syndrome. In: Wein et al.,. Campbell-Walsh Urology, 9th ed. Philadelphia, PA: Saunders; 2007;
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Basic Information

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  • The Online Mendelian Inheritance in Man (OMIM) is an catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine. 
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs.  Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Prune belly syndrome. Click on the link to view a sample search on this topic.
Other Names for this Disease
  • Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism
  • Eagle-Barrett syndrome
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.