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Genetic and Rare Diseases Information Center (GARD)

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Pityriasis lichenoides chronica

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Your Question

I was diagnosed with pityriasis lichenoides chronica over 11 years ago. I have tried all sorts of different medications. I started taking methotrexate about 6 weeks ago, but haven't seen any changes yet. How long does it usually take for this medication to take effect? What are some other treatment options? What are the chances that there will be a cure for this condition? Can it spontaneously resolve? If the condition does resolve, what are the chances that it will come back?

Our Answer

We have identified the following information that we hope you find helpful. If you still have questions, please contact us.

How might pityriasis lichenoides chronica be treated?

Pityriasis lichenoides chronica may not always respond to treatment and relapses often occur when treatment is discontinued. If the rash is not causing symptoms, treatment may not be necessary. In cases where treatment is necessary, there are several different therapies available.[1]

First-line therapies may include:[1]

Second-line therapies may include:[1]

Third-line therapies may include:[1]

, a searchable database of medical literature, lists several journal articles that discuss treatment of pityriasis lichenoides chronica. Click on the link to view abstracts of articles related to this topic.
Last updated: 4/30/2010

How long might it take for patients with pityriasis lichenoides chronica to respond to methotrexate?

It may take 3-6 weeks for patients with pityriasis lichenoides chronica to respond to methotrexate. In some cases, the dosage of this medication may need to be adjusted in order to obtain a satisfactory response.[2]
Last updated: 4/30/2010

What are the chances that there will be a cure for pityriasis lichenoides chronica?

At this time, there is no cure for this condition.[3] We are not able to comment on the chances that there will, someday, be a cure.
Last updated: 4/30/2010

Can pityriasis lichenoides chronica spontaneously resolve?

While the lesions associated with pityriasis lichenoides chronica may take time to respond to treatment and the duration of the disease cannot be predicted, most cases tend to resolve over time. Many cases resolve spontaneously without treatment.[2][4]
Last updated: 4/30/2010

What are the chances that pityriasis lichenoides chronica will reoccur?

Relapses of pityriasis lichenoides chronica are common, particularly when treatment is discontinued.[1]
Last updated: 4/30/2010