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Genetic and Rare Diseases Information Center (GARD)

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Pigmented villonodular synovitis

Other Names for this Disease
  • Diffuse pigmented villonodular synovitis
  • Localized pigmented villonodular synovitis
  • Tenosynovial giant cell tumors
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How might pigmented villonodular synovitis be treated?

Pigmented villonodular synovitis is first treated with surgery to remove as much of the abnormal tissue growth as possible.  The type of surgery depends on the location and extent of the disease within the joint.  Radiation therapy is sometimes used to treat this condition if surgery is not an option, or if the condition returns (recurs) after an initial surgery.[1]  More recently, research is being done on the use of certain medications (systemic therapy), such as imatinib and sunitinib, to treat this condition.[2]
Last updated: 11/28/2011

  1. Mendenhall WM, Mendenhall CM, Reith JD, Scarborough MT, Gibbs CP, Mendenhall NP. Pigmented Villonodular Synovitis. American Journal of Clinical Oncology. 2006; 29:548-550. Accessed 11/22/2011.
  2. Ravi V, Wang WL, Lewis VO. Treatment of tenosynovial giant cell tumor and pigmented villonodular synovitis. Current Opinion in Oncology. 2011; 23:361-366. Accessed 11/22/2011.

Clinical Trials & Research for this Disease

  • lists trials that are studying or have studied Pigmented villonodular synovitis. Click on the link to go to to read descriptions of these studies.